Emerging Therapies and Diagnostic Tools. Emerging Therapies & Diagnostic Tools News Feed. Aug. 2. 8, 2. 01.

In a pre- print, Duke University researchers say that in 1. The investigation combined transcranial magnetic stimulation to the dorsolateral prefrontal cortex, f. MRI, and diffusion weighted imaging. A research letter describes using noninvasive vagus nerve stimulation in the headache disorders paroxysmal hemicranial and hemicranial continua in which medical treatment with indomethacin is not tolerated. An article says bioelectronic medicine devices to stimulate peripheral nerves for chronic conditions may appear by the mid- 2. The article said the treatments would modulate organ function, such as hormone production or airway constriction. International Neuromodulation Society member Bomin Sun, MD and colleagues reported in Parkinsonism and Related Disorders about long- term followup in 1.

Marilyn Manson performing in 2017.

The patients' movement and disability scores improved 8. Follow- up lasted as long as 8. A research team reports on a randomized controlled clinical trial in which percutaneous electrical nerve field stimulation was applied to the external ear to relieve pain in 1. Patients in the treatment group had greater pain reduction after three weeks, compared to sham.

An article profiles a spine- injured patient who was the first participant in a clinical trial of a cortical implant that bypasses his injured spine and allows him to move his paralyzed hand and arm. International Neuromodulation Society member Ali Rezai, MD, is a medical director of the project. The research team published a paper about their work in Scientific Reports. A man with tardive dystonia became the first adult to receive deep brain stimulation at a state hospital in the Western Cape in South Africa. International Neuromodulation Society member Bart Billet, MD, and colleagues report in PAIN Practice on a case of a 7. International Neuromodulation Society President Timothy Deer, MD, is quoted in an article about spinal cord stimulation (SCS). The article notes drawbacks of longterm opioid treatment, and says that with its technical advancements, SCS is poised to become a mainstay in chronic pain treatment.

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International Neuromodulation Society member Andre Machado, MD, Ph. D, presented results of a 1. American Association of Neurological Surgeons.

Stimulation that targeted the affective, emotional aspect of pain led to a change in perception and emotion but disability associated with pain remained unchanged. An article describes progress made by the first enrollee in a clinical study of deep brain stimulation to augment stroke recovery. International Neuromodulation Society member Andre Machado, MD, Ph. D, the investigator, will work with the FDA to change the study protocol so the patient can continue to receive stimulation after four months because she has continued to make progress, without a plateau as had initially been anticipated by the original study design. The International Neuromodulation Society Chinese chapter will honor the first winner of the Science & PINS Prize for Neuromodulation on Sept. Annual Meeting of Chinese Neuromodulation Society & The 8th Neuromodulation Congress of China in Jinan, Shandong Province, China. Download Absolution (2015) Online here. The winner of the $2.

University of Maryland Assistant Professor Meaghan Creed, Ph. D, submitted an essay for publication in the journal about her work showing a reversal of addictive symptoms in mice exposed to cocaine through deep brain stimulation (DBS) plus a drug to inhibit dopamine D1 receptors. In the mouse model of cocaine addiction, combining neurostimulation and a receptor antagonist showed an effect similar to the reversal seen in mice treated with optogenetics. Ontogenetic tools initially provided insight into how the plasticity of the brain's reward system is altered by exposure to addictive drugs. DBS alone was ineffective in addressing the symptoms in the mice. She explained in her essay that using a precise circuit- based intervention was key: . A study of 4. 9 people with schizophrenia in the journal Brain explored whether transcranial direct current stimulation might address problems with working memory and executive function that impair daily function for people with the condition.

The double- blind, sham- controlled study found significant improvement in working memory 2. Twenty- eight subjects also had a functional MRI exam, and the study tracked improvements in an executive function task with changes in activity in the anterior cingulate cortex, task- related brain regions, and more distal nodes. The authors say the mode of action, therefore, is not just limited to stimulation of basal ganglia brain centers. They suggest that when deep brain structures are not the primary target, therapeutic terms such as . By contrast, the number of augmentation cystoplasty procedures remained stable, with 1. Proportionally, the augmentation procedure dropped from 2.

The prospective multi- center study enrolled 3. In the study, 6. 8 patients received standard drug therapy, and the remainder received a sacral nerve stimulation implant.

One- third of the patients also received spinal cord stimulation simultaneously. The patients primarily had failed back surgery syndrome or low back pain. An article says that previously the state did not have a dedicated, multi- disciplinary program to address movement disorders in a comprehensive way. The new treatment program is expected to integrate complementary medicine and yoga.

The study is being funded by the National Institute for Health Research. The work may address blindness, paralysis and speech disorders through such means as light- emitting diodes, sensors linked to systems designed to decode speech, and detecting neural activity with holographic microscopes.

Engadgetreported that the lead organizations are Brown University, Columbia University, The Seeing and Hearing Foundation, the John B. Pierce Laboratory, Paradromics Inc.

The award came through DARPA's new Neural System Engineering Design program. The article includes perspectives from International Neuromodulation Society members Giancarlo Baronet, MD; Christophe Perruchoud, MD; and Simon Thomson, MD. Its editor, International Neuromodulation Society member Jane Shipley, attributes that growth to her presentations made at the INS 1. World Congress. In the monthly newsletter, she acknowledged INS Director- at- Large Konstantin Slavin for mentioning the resource during his presentations as well. With an additional 3. May, the registered users now number 5.

The work was published in May 2. Annals of Neurology. Co- authors included fellow INS members Scott Lempke, Ph. D and Kenneth Baker, Ph. D. In the nine patients in the cross- over trial, active stimulation did not produce at least a 5.

Up to 2. 5 patients may eventually be included in the study. The abstracts about pain and movement disorder were presented in a plenary session during the opening day of the congress. He describes devices becoming smarter so they can evaluate the response of the body and make changes in real time, as well as work in the brain to find new targets to treat diseases and conditions that are not optimally treated by pharmaceutical options. The intent is to develop approaches to conditions such as Parkinson's disease, chronic pain, and potentially also stroke or depression. Department of Defense's Advanced Research Program Agency, DARPA, is funding eight projects at seven U. S. The group that received 1.

Hz stimulation plus topiramate had significant decreases in headache duration. The overall research explored combinations of working memory training in groups of 7.

DCS administered to the left dorsolateral prefrontal cortex, and some to the right. Results appeared in the journal Neuropsychologia. The study involved 2. 1080P Hd Video Download Whiskey Tango Foxtrot (2016) on this page. Despite a 2. 5% complication rate, all patients said they would recommend the therapy to patients with similar symptoms. However, they write that published findings indicate .

The study in Current Biology was funded by the U.

In Image's Redlands, Witches Are Feared Not Just for Their Magic, But Because They're Women. Witches have come in all shapes, sizes, and powers over the centuries, but there’s one thing they usually have in common: They’re women. Image’s powerful series Redlands highlights the link between womanhood and witchcraft, showing the misogyny behind the mythology. It is impossible to talk about witchcraft without unpacking how fears about witches have been used as shorthand for real sexism. These parallels go back hundreds of years, targeting midwives, widows, and other women who existed outside of accepted norms of their time periods.

It’s an issue that’s been explored in countless stories about witches, from Arthur Miller’s critically acclaimed play The Crucible to the 1. The Craft. Robert Egger’s 2. The Witch, for example, is both literally a film about a family being terrorized by an actual witch and about how, when faced with labeled as being “different” by conventional standards, there was a point in time when women were summarily accused of witchcraft. In a disturbing, beautiful way, co- creators Jordie Bellaire and Vanesa Del Rey’s Redlands out today from Image revels in the idea that magic is born from unholy contracts between the devil and clever women. But it’s noticeably careful about making sure you understand that the terror and fear on the page is entirely subjective, and coming from the non- witches’ perspective. A tree engulfed in flames with three nooses swinging from its branches in the roaring fire stands at the center of Redlands’ first panel. Somewhere off in the distance, an unseen man huddled in a police station curses to himself (and everyone around him) that the lynching and burning at the stake they’d attempted has failed.

The witches have escaped, the humans are fucked, and everyone knows it. There’s little in the way of explanation as to exactly what happened in the scenes leading up to the book’s opening, but there’s enough to convey strong emotions in the absence of specific details.

A group of local men—the town’s police force—are holed up in the police department as the witches move through the shadowy forest, daring them to step out into the light of the fire. In another story, you might feel sympathy for the men and be able to see them as the unlucky victims of Redlands’ demons, were it not for the handful of simple but heavy bits of character detail that co- creators Bellaire and Del Rey carefully place into each panel. Both we and these men know that they’re dealing with the supernatural, but to them, their adversaries are “bitches” before they’re witches, establishing one of the key elements of Redlands’ world- building. You get the distinct sense that the people of Redlands, Florida, fear the trio of witches for their magic, but they hate them because they’re women—exercising a sort of power that the men of the town are not prepared to handle. As the policemen cower in their Confederate flag- lined station, the witches tease and play them from the outside, casting illusions to trick the men into repeatedly opening the door and even leaving, only to be promptly eviscerated by the literal demons waiting for them.

While Redlands may initially lull you into seeing the witches as the book’s ultimate threat, Bellaire and Del Ray have the policemen turn inward on themselves. Their reflections deftly gesture to the fact that evil lived in the town long before the witches showed up. In the darkness of their building where they assume they’re safe, the policemen butt up against the prisoners lucky enough to be locked up that night and, in their interactions, you see that the lawmen aren’t exactly friendly with the locals. Racially- charged tension crackles between an imprisoned black man and the white officer on the other side of the bars. The officer goads the prisoner with a flippant remark about being named after his absentee father. The prison responds by reminding the officer that his father’s only missing because the officer’s father killed him. Whatever horrors the witches may have brought to their town, the comic makes it clear it’s bound to be no worse than Redlands’ status quo.

Women like the witches, one of the police men spits, are begging for it. And in a way he’s right, the witches are eagerly awaiting for him and all of his friends to just come outside and talk things over—to clear up any and all misunderstandings between their respective parties. But when the town sheriff does ultimately come forward to confront the witches and drive them away with his shotgun, there’s a subtle shift in Redlands’ tone that sets the stage for what the rest of the series holds. The witches haven’t just descended upon Redlands for their own amusement, or even to scare its citizens. Redlands was sick and bloated with evil and rot before the witches set foot in the town. Del Rey’s kinetic illustrations and the shadowy, bloody shades of red Bellaire fills the page with are meant to make you feel the fear surging through the non- witches. But beneath that fear is a deeper understanding that sometimes, this is what change for the better looks and feels like when you’re a part of the problem.

Seen from another perspective using a little imagination, the witches’ impending massacre of the police isn’t something to fear—it’s an attempt at healing the town. Almost every story about the persecution of women suspected of witchcraft is also a story about a society unable or unwilling to accept women as competent, powerful people. Darker, more psychological witch tales sometimes tease us as to whether the suspected witchcraft is actually real. Redlands manages to be both kinds of stories while leaving you with the distinct feeling that it’s less of a gritty children’s story retooled for adults and more of a cautionary tale about what happens when you run afoul of the wrong women.